When Anna Delite Spink was born on 11 February 1842, in Kane, Illinois, United States, her father, Solomon Gregory Spink, was 31 and her mother, Roxanna Barrus, was 28. She married John Francis Appleby on 16 October 1866, in Mazomanie, Dane, Wisconsin Territory, United States. They were the parents of at least 2 sons and 1 daughter. She lived in Black Earth, Dane, Wisconsin, United States in 1860 and Wisconsin, United States in 1870. She died on 26 April 1923, in Los Angeles, Los Angeles, California, United States, at the age of 81.