When Uriah Tilton was born on 15 November 1713, in Chilmark, Dukes, Massachusetts, United States, his father, Josiah Tilton, was 43 and his mother, Bathsheba Mayhew, was 32. He married Jedidah Mayhew on 16 March 1737, in Chilmark, Dukes, Massachusetts, United States. They were the parents of at least 6 sons and 4 daughters. He died on 1 January 1788, in his hometown, at the age of 74, and was buried in Chilmark, Dukes, Massachusetts, United States.