When Ephraim Wildes was born on 3 September 1693, in Topsfield, Essex, Massachusetts Bay Colony, British Colonial America, his father, Ephraim Wildes, was 27 and his mother, Mary Howlett, was 22. He married Hepzibah Peabody on 31 January 1731, in Topsfield, Essex, Massachusetts Bay Colony, British Colonial America. They were the parents of at least 6 sons and 4 daughters. He died on 3 April 1767, in his hometown, at the age of 73.