When Alexander Mebane was born on 10 February 1787, in Caswell, North Carolina, United States, his father, David Mebane, was 26 and his mother, Ann Allen, was 20. He married Frances Mitchell on 26 September 1818, in Caswell, North Carolina, United States. They were the parents of at least 5 sons and 4 daughters. He lived in Alamance, Alamance, North Carolina, United States in 1850. He died on 16 December 1865, in Alamance, North Carolina, United States, at the age of 78.