When Luther Spalding was born on 7 August 1791, in Greene, Greene, Chenango, New York, United States, his father, Parley Spalding, was 30 and his mother, Abigail Joselyn, was 26. He married Sally Maria Stocker on 30 January 1823. They were the parents of at least 2 sons and 4 daughters. He lived in Amherst, Amherst, Erie, New York, United States in 1855 and Amherst, Erie, New York, United States in 1860. He died on 23 September 1860, in Williamsville, Amherst, Erie, New York, United States, at the age of 69.