When Judge Ephraim Brevard Ewing was born on 16 May 1819, in Todd, Kentucky, United States, his father, Rev. Finis Ewing, was 45 and his mother, Margaret Brevard Davidson, was 45. He married Elizabeth Ann Allen on 18 July 1835, in Ray, Missouri, United States. They were the parents of at least 4 sons and 6 daughters. He lived in Jefferson City, Cole, Missouri, United States in 1860 and St. Louis, St. Louis, Missouri, United States in 1870. He died on 21 June 1873, in Iron Mountain, St. Francois, Missouri, United States, at the age of 54, and was buried in Bellefontaine Cemetery, St. Louis, St. Louis, Missouri, United States.