When Lewis Johnson Gregory was born on 4 January 1843, in Ohio, United States, his father, David Gregory, was 42 and his mother, Charity Cummins, was 37. He married Nancy L McGlaughlin on 29 December 1865, in Vinton, Ohio, United States. They were the parents of at least 3 sons and 2 daughters. He lived in Knox, Vinton, Ohio, United States in 1880 and Wilkesville, Wilkesville Township, Vinton, Ohio, United States in 1900. He registered for military service in 1865. He died on 15 November 1915, in Wilkesville, Vinton, Ohio, United States, at the age of 72, and was buried in Wilkesville, Vinton, Ohio, United States.