When Charles Reuben Blackwelder was born on 18 March 1805, in Cabarrus, North Carolina, United States, his father, Martin Wiley Blackwelder, was 38 and his mother, Elizabeth Meisenheimer, was 38. He married Catherine Elizabeth Lipe on 18 May 1825, in Cabarrus, North Carolina, United States. They were the parents of at least 7 sons and 6 daughters. He lived in Cabarrus, Cabarrus, North Carolina, United States in 1850 and North Carolina, United States in 1870. In 1860, at the age of 55, his occupation is listed as farmer in China Grove, Rowan, North Carolina, United States. He died on 10 October 1878, in Cabarrus, North Carolina, United States, at the age of 73, and was buried in Saint Johns Evangelical Lutheran Church Cemetery, Concord, Cabarrus, North Carolina, United States.