When John Henderson was born in 1780, in Halifax, Halifax, Virginia, United States, his father, Edward Henderson, was 34 and his mother, Lydia Rice, was 35. He married Sarah Clark on 11 December 1806. They were the parents of at least 2 sons and 6 daughters. He lived in Allegany, Maryland, United States in 1850. He died on 5 December 1841, in Halifax, Halifax, Virginia, United States, at the age of 61.
English and Scottish: usually from Middle English and Older Scots Hener(i)son ‘Henry's son’, occasionally from Middle English Hendeson ‘son of Hen’, a pet form of Henry , both with an intrusive -d-. Compare Hendrie . In Scotland Henderson was sometimes substituted for McKendrick .