When Isaac Malone was born on 5 June 1802, in Greenbriar, Chesterfield, Virginia, United States, his father, Richard Malone Sr, was 26 and his mother, Susannah Weaver, was 24. He married Mary Polly Perry on 13 April 1826, in Scioto, Ohio, United States. They were the parents of at least 3 sons and 5 daughters. He died on 15 November 1881, in Vernon Township, Scioto, Ohio, United States, at the age of 79, and was buried in Vernon Cemetery, Ashley Corner, Scioto, Ohio, United States.