When Polly Margaret Paisley was born on 25 January 1803, in Guilford, North Carolina, United States, her father, John Paisley, was 38 and her mother, Jane Rankin, was 31. She married Joseph Paisley on 9 August 1822, in Guilford, North Carolina, United States. They were the parents of at least 3 sons and 3 daughters. She died on 2 December 1836, in Illinois, United States, at the age of 33, and was buried in Donneilson Cemetery, Donnellson, Montgomery, Illinois, United States.