When James W. E. Gulledge was born on 18 September 1846, in Coosa, Alabama, United States, his father, Joel Houston Gulledge, was 35 and his mother, Elizabeth Duke Mitchell, was 43. He married Louisa Smith Wyatt about 1866, in Alabama, United States. They were the parents of at least 6 sons and 4 daughters. He lived in Cooper, Chilton, Alabama, United States in 1900. He registered for military service in 1907. He died on 20 March 1936, in Chilton, Chilton, Alabama, United States, at the age of 89, and was buried in Verbena Cemetery, Verbena, Chilton, Alabama, United States.