When Jefferson Wamsley was born on 18 January 1852, in Putnam, Ohio, United States, his father, James David Wamsley, was 49 and his mother, Sarah Bushong, was 38. He married Julia Frances Booher on 13 July 1876, in Grundy, Missouri, United States. They were the parents of at least 4 sons and 4 daughters. He lived in Pleasant Township, Putnam, Ohio, United States in 1860 and Missouri, United States in 1870. He died on 10 May 1904, in Trenton, Grundy, Missouri, United States, at the age of 52, and was buried in Maple Grove Cemetery, Trenton Township, Grundy, Missouri, United States.