When Isabella Lowes was born on 21 August 1831, in Cavan, Durham, Ontario, Canada, her father, Joseph Lowe, was 32 and her mother, Sarah Shield, was 26. She married John Withers Uren III about 1852, in Oxford, Ontario, Canada. They were the parents of at least 3 sons. She died on 19 February 1902, in North Oxford, Oxford, Ontario, Canada, at the age of 70, and was buried in West Oxford, Oxford, Ontario, Canada.