When Thomas Jefferson Nixon was born on 21 October 1853, in Fort Smith, Sebastian, Arkansas, United States, his father, Andrew Jackson Nixon I, was 40 and his mother, Lurana Lorraine Wootten, was 38. He married Melcena Kennar Kuykendall on 6 October 1878, in Gillespie, Texas, United States. They were the parents of at least 7 sons and 2 daughters. He lived in Justice Precinct 5, Gillespie, Texas, United States in 1910 and Justice Precinct 1, Brown, Texas, United States in 1930. He died on 28 May 1930, in Brown, Texas, United States, at the age of 76, and was buried in Pleasant Valley Cemetery, Owens, Brown, Texas, United States.