When David Frambes was born on 15 September 1790, in Clarks Landing, Atlantic, New Jersey, United States, his father, Nicholas Frambes, was 32 and his mother, Sarah Rape, was 30. He married Louisa Clark on 15 April 1825, in Burlington, New Jersey, United States. They were the parents of at least 2 sons and 5 daughters. He lived in Egg Harbor Township, Atlantic, New Jersey, United States for about 10 years and Atlantic City, Atlantic, New Jersey, United States in 1865. He died on 28 April 1867, at the age of 76, and was buried in Egg Harbor Township, Atlantic, New Jersey, United States.