When Brigadier General Isaac Zane was born on 26 April 1743, in Philadelphia, Pennsylvania, United States, his father, Isaac Zane, was 33 and his mother, Sarah Elfreth, was 33. He married Elizabeth " Betsy" McFarland from 1774 to 1808. They were the parents of at least 1 son. He died on 22 August 1795, in Pennsylvania, United States, at the age of 52.
English (Devon): apparently a nickname from Middle English seine ‘cured, healed’, with West Country voicing of the initial fricative consonant.
Italian (Venice and Mantua): from a variant of the Venetian personal name Z(u)an(n)i ‘John’ (see Zanni ).
Americanized form of German and Jewish (Ashkenazic) Zahn .