When Hepzibah Humphrey was born in 1767, in Simsbury, Hartford, Connecticut, United States, her father, Theophilus Humphrey Sr., was 23 and her mother, Hepzibah Cornish, was 25. She married Jesse Barber in 1787, in West Simsbury, Simsbury, Hartford, Connecticut, United States. They were the parents of at least 4 sons and 6 daughters. She lived in Fairfield, Franklin, Vermont, United States in 1790. She died on 21 January 1848, in Swanton, Franklin, Vermont, United States, at the age of 81, and was buried in Greens Corners Cemetery, Swanton, Franklin, Vermont, United States.