When James Warren Sr was born on 12 January 1770, in Randolph, North Carolina, United States, his father, William Warren, was 30 and his mother, Anne Wilcox, was 30. He married Sarah Williams in 1791, in Orange, North Carolina, United States. They were the parents of at least 8 sons and 5 daughters. He lived in Wayne, Indiana, United States in 1820. He died in November 1839, in Henry, Indiana, United States, at the age of 69, and was buried in Henry, Indiana, United States.