When Heinrich Wettstein was born about 1747, in Zürich, Switzerland, his father, Hans Ulrich Wettstein, was 79 and his mother, Margaretha Keller, was 77. He married Anna Binder on 30 August 1840, in Wildberg, Zürich, Switzerland. They were the parents of at least 1 daughter. He died on 13 December 1753, at the age of 6.