When Sophronia Hamblin was born on 22 July 1818, in Becket, Berkshire, Massachusetts, United States, her father, Levi Hamblin, was 44 and her mother, Agnes Hoskins, was 27. She married George Humphrey on 11 September 1837, in Hartford, Connecticut, United States. They were the parents of at least 2 sons and 2 daughters. She lived in Connecticut, United States in 1870 and Bloomfield, Hartford, Connecticut, United States in 1880. She died on 16 January 1900, in Avon, Hartford, Connecticut, United States, at the age of 81, and was buried in Mountain View Cemetery, Bloomfield, Hartford, Connecticut, United States.