When Ephraim Patterson Ralston was born on 21 December 1844, in Smithfield, Jefferson, Ohio, United States, his father, George Washington Ralston, was 21 and his mother, Sidney Jane Courtright, was 20. He married Emma Jane Dawson in 1867. They were the parents of at least 1 son and 4 daughters. He lived in Oberlin, Lorain, Ohio, United States in 1910 and Russia Township, Lorain, Ohio, United States in 1920. He died on 9 May 1923, at the age of 78.
Scottish: habitational name from Ralston (Renfrewshire), composed of the personal name Raoul, a vernacular form of Ralph , + Scots toun ‘farm, village’.