When Florence Applegate was born on 5 February 1857, in Yoncalla, Douglas, Oregon, United States, her father, Jesse M Applegate, was 45 and her mother, Cynthia Ann Parker, was 43. She married Henry Clay Long on 18 October 1874, in Douglas, Oregon, United States. They were the parents of at least 2 sons and 3 daughters. She lived in Hamilton, Grant, Oregon, United States in 1900 and Election Precinct 7 North Fork, Grant, Oregon, United States in 1910. She died on 22 July 1916, in Douglas, Oregon, United States, at the age of 59, and was buried in Masonic Cemetery, Douglas, Oregon, United States.