When William Griffin was born on 20 August 1772, in Westchester, New York Colony, British Colonial America, his father, Adam Griffin I, was 31 and his mother, Deborah Bedford, was 28. He married Amy Willets on 22 April 1796, in New York, United States. They were the parents of at least 2 sons and 9 daughters. He died on 20 August 1836, in Ellenville, Wawarsing, Ulster, New York, United States, at the age of 64, and was buried in Old Ellenville Cemetery, Ellenville, Wawarsing, Ulster, New York, United States.