When Priscilla Tompkins was born on 20 October 1776, in Little Compton, Newport, Rhode Island, United States, her father, Gamaliel Tompkins, was 25 and her mother, Mary Church, was 21. She married Isaac Brownell on 4 May 1800, in Little Compton, Newport, Rhode Island, United States. They were the parents of at least 1 son and 2 daughters. She died on 13 October 1821, in her hometown, at the age of 44, and was buried in Little Compton, Newport, Rhode Island, United States.