When George W Lesher was born on 10 January 1812, in Herkimer, New York, United States, his father, George Lesher, was 32 and his mother, Isabel, was 28. He married Barbara Hayden in 1835, in New York, United States. They were the parents of at least 3 daughters. He lived in Gaines, Orleans, New York, United States for about 10 years and New York, United States in 1870. He died on 11 April 1857, in Albion, Albion Town, Orleans, New York, United States, at the age of 45.