When Mary Anderson was born on 13 February 1761, in Rockbridge, Virginia, United States, her father, Isaac Anderson II, was 31 and her mother, Margaret Evans, was 27. She married Andrew McCampbell on 7 April 1781. They were the parents of at least 5 sons and 6 daughters. She died on 3 April 1838, in Knox, Tennessee, United States, at the age of 77, and was buried in Knox, Tennessee, United States.