Margaret McGuffin was born on 15 December 1797, in Virginia, United States as the daughter of Samuel Booker McGuffin and Mary E Fleming. She married John Shy on 3 January 1816, in Mercer, Kentucky, United States. They were the parents of at least 1 daughter. She lived in Kansas Township, Edgar, Illinois, United States in 1860. She died on 14 February 1867, at the age of 69, and was buried in Pleasant Hill Cemetery, Kansas Township, Edgar, Illinois, United States.
Irish: variant of McGaffin 1.