When Cynthia Winsor was born on 20 May 1765, in Smithfield, Providence, Rhode Island, United States, her father, Rev. John Winsor, was 42 and her mother, Mercy Smith, was 38. She married Nicholas Otis in 1788. They were the parents of at least 4 sons and 2 daughters. She died in 1847, in New York City, New York, United States, at the age of 82.