James Brain was born on 30 January 1825, in Trentham, Staffordshire, England, United Kingdom as the son of James Brain and Mary Shaw. He married Eliza Elise Jane Sanborn on 18 November 1845, in Cuyahoga, Ohio, United States. They were the parents of at least 3 sons and 2 daughters. He immigrated to United States in 1839 and lived in Kirtland, Lake, Ohio, United States in 1880 and Kirtland Township, Lake, Ohio, United States in 1900. He died on 8 October 1910, in Perkins, Erie, Ohio, United States, at the age of 85.
English: apparently a nickname from Middle English brain ‘brain, mind’, probably short for brainwod ‘mad in the mind, furious’. Compare Brainard .
Irish (Down) and Scottish: shortened Anglicized form of Irish Mac an Bhreitheamhan, Scottish Gaelic Mac a' Bhreitheamhan ‘son of the judge’, from breitheamh ‘judge’. Compare Braham 2.