When Israel Comstock was born on 7 January 1799, in Saratoga Springs, Saratoga, New York, United States, his father, Solomon Comstock, was 23 and his mother, Elizabeth Comstock, was 24. He married Elizabeth Betsy Fuller on 1 April 1823, in Otsego, New York, United States. They were the parents of at least 9 sons and 3 daughters. He lived in Ronald Township, Ionia, Michigan, United States in 1850 and Bushnell Township, Montcalm, Michigan, United States in 1860. He died on 6 June 1862, in Palo, Ionia, Michigan, United States, at the age of 63, and was buried in Palo, Ionia, Michigan, United States.