When Mary Matilda Simpson was born on 23 July 1809, in Washington, Kentucky, United States, her father, James Montgomery Simpson, was 25 and her mother, Mary Alice Boone, was 28. She married John Burtle about 1828, in Kentucky, United States. They were the parents of at least 1 son and 2 daughters. She lived in Cinque Hommes Township, Perry, Missouri, United States in 1850. She died on 23 May 1852, in Perry, Missouri, United States, at the age of 42, and was buried in St. Mary, Ste. Genevieve, Missouri, United States.