When Samuel Vermillian Simpson was born about 1827, in Randolph, Arkansas, United States, his father, William Samuel Simpson, was 25 and his mother, Nancy, was 51. He married Martha Alice Cloud on 22 March 1853, in Springfield, Greene, Missouri, United States. They were the parents of at least 2 sons and 2 daughters. He lived in Chico Judicial Township, Butte, California, United States in 1860. He died on 21 August 1877, in Los Angeles, Los Angeles, California, United States, at the age of 50.