When Barbara Fleisher was born in 1765, in Highland, Virginia, United States, her father, Johannes Peter Fleischer, was 44 and her mother, Anna Maria Thiel, was 41. She married Adam Harper in 1785. They were the parents of at least 4 sons and 5 daughters. She died in 1834, in Ross, Ohio, United States, at the age of 69, and was buried in Concord Presbyterian Church Cemetery, Lattaville, Ross, Ohio, United States.