When Lena M. Jefferson was born on 14 May 1882, in Republic, Kansas, United States, her father, Iverson Alverian “Iva” Jefferson, was 27 and her mother, Sarah Jane Davenport, was 24. She married William Edward Frame on 25 October 1900, in Washington, Kansas, United States. They were the parents of at least 1 son and 1 daughter. She lived in Esculapia Township, Benton, Arkansas, United States for about 10 years. She died on 9 August 1922, in Benton, Arkansas, United States, at the age of 40, and was buried in Rogers Cemetery, Rogers, Benton, Arkansas, United States.