When Stephen Robert Talkington was born on 20 August 1849, in Arkansas, Arkansas, United States, his father, Isaac Walton Talkington, was 27 and his mother, Mary A. T. Eshom Eschom, was 27. He married Theodocia Ernestine Waggoner on 1 November 1877, in Fannin, Texas, United States. They were the parents of at least 4 sons and 1 daughter. He lived in Texas, United States in 1870 and Justice Precinct 2, San Saba, Texas, United States in 1880. He died on 28 April 1912, in Ardmore, Carter, Oklahoma, United States, at the age of 62, and was buried in Mill Creek Post Office, Johnston, Oklahoma, United States.