When Martha McMillan was born on 21 August 1801, in Tazewell, Tazewell, Virginia, United States, her father, Andrew McMillin, was 28 and her mother, Nancy King, was 22. She married Robert Floyd Sayers on 11 February 1827, in Tazewell, Virginia, United States. They were the parents of at least 4 sons and 5 daughters. She died on 9 January 1839, in Tippecanoe, Indiana, United States, at the age of 37, and was buried in New Richmond, Coal Creek Township, Montgomery, Indiana, United States.