When Francisca Simona López de Guzmán De Guez was born in 1708, in Mocorito, Mocorito, Sinaloa, Mexico, her father, Ignacio López de Ayala Ruiz de Aldana, was 18 and her mother, Nicolasa López de Guzmán Félix, was 13. She had at least 9 sons and 3 daughters with Agustín Camacho. She lived in Agua Caliente, Badiraguato, Sinaloa, Mexico in 1750. She died on 11 February 1756, in Mocorito, Sinaloa, Mexico, at the age of 48, and was buried in Mocorito, Sinaloa, Mexico.