When David Regester was born about 1744, in Chester, Pennsylvania, British Colonial America, his father, Robert Regester, was 26 and his mother, Jane Williamson, was 19. He married Margaret Black on 7 October 1768, in Edgemont, Edgmont Township, Delaware, Pennsylvania, United States. They were the parents of at least 4 sons. He died in 1781, in Edgmont Township, Chester, Pennsylvania, United States, at the age of 37, and was buried in Edgmont Township, Chester, Pennsylvania, United States.