When Samuel Miller Swisher was born about 1821, in Pennsylvania, United States, his father, John Henry Swisher, was 36 and his mother, Mary Magdalena Henry, was 37. He married Elizabeth Knapp Minnerly on 30 December 1840, in Richland, Ohio, United States. They were the parents of at least 2 sons and 4 daughters. He lived in Tod Township, Crawford, Ohio, United States in 1850 and Mendota, LaSalle, Illinois, United States for about 20 years. He died on 28 July 1907, in Ohio, United States, at the age of 86, and was buried in Mendota, LaSalle, Illinois, United States.