When Deborah Delong Masters was born on 7 April 1794, in Virginia, United States, her father, Hillery Masters, was 36 and her mother, Mary Davies, was 36. She married Robert George Washington Cain about 1815, in Overton, Tennessee, United States. They were the parents of at least 5 sons and 3 daughters. She lived in Overton, Tennessee, United States in 1850. She died on 9 August 1870, in Greene, Illinois, United States, at the age of 76, and was buried in Jones Cemetery, White Hall Township, Greene, Illinois, United States.