When William Payne was born about 1725, in Hanover, Virginia, British Colonial America, his father, William Payne, was 40 and his mother, Elizabeth Poindexter, was 25. He married Ruth Lewis about 1742, in Virginia, United States. They were the parents of at least 2 sons and 4 daughters. He died in 1771, in Halifax, Virginia, British Colonial America, at the age of 46, and was buried in South River Meeting House Graveyard, Lynchburg, Campbell, Virginia, United States.