When John Charles III was born on 28 September 1685, in Springfield, Hampshire, Massachusetts Bay Colony, British Colonial America, his father, Samuel Charles, was 29 and his mother, Abigail Wheeler, was 25. He married Elizabeth Swetman on 10 March 1708, in Springfield, Hampden, Massachusetts, United States. They were the parents of at least 4 sons and 2 daughters. He died about 1739, in Boston, Suffolk, Massachusetts Bay Colony, British Colonial America, at the age of 54.