When Luther Hiscock was born on 7 January 1801, in Pompey, Onondaga, New York, United States, his father, Richard Hiscock, was 42 and his mother, Sarah Cody, was 37. He married Persis Higbee on 7 March 1832, in Pompey, Onondaga, New York, United States. They were the parents of at least 3 sons and 5 daughters. He died on 1 May 1879, in Flint, Genesee, Michigan, United States, at the age of 78, and was buried in Jackson, Jackson, Michigan, United States.