When George Richard Wissler was born on 15 May 1850, in Gettysburg, Adams, Pennsylvania, United States, his father, Jacob Hiestand Wissler, was 23 and his mother, Margaretta Bowen, was 22. He married Susan Ellen Frisbie on 30 May 1881, in Le Roy, Mower, Minnesota, United States. They were the parents of at least 1 son and 1 daughter. He lived in Iowa, United States in 1870 and Pleasant Valley Township, Cerro Gordo, Iowa, United States in 1880. He died on 17 March 1896, in Crescent City, Putnam, Florida, United States, at the age of 45, and was buried in Eden Cemetery, Crescent City, Putnam, Florida, United States.