When Thomas Witten Sayers was born on 28 June 1814, in Jeffersonville, Tazewell, Virginia, United States, his father, Alexander Sayers, was 42 and his mother, Susannah Cecil, was 37. He married Margaret Ann Munsey on 24 January 1839, in Tazewell, Virginia, United States. They were the parents of at least 3 sons and 7 daughters. He lived in Taylor Township, Greene, Missouri, United States for about 40 years. He died on 21 March 1906, in Green Township, Hickory, Missouri, United States, at the age of 91, and was buried in Greene, Missouri, United States.