When Isaac Elsworth Rhodes was born in May 1862, in Fulton, Indiana, United States, his father, Thomas Jefferson Rhodes, was 46 and his mother, Susannah Good, was 39. He married Alice E. Fribley on 12 October 1886, in Marshall, Indiana, United States. They were the parents of at least 5 sons and 3 daughters. He lived in Wishkah, Grays Harbor, Washington, United States in 1930 and Hoquiam Election Precinct, Grays Harbor, Washington, United States in 1940. He died on 26 March 1951, in Seattle, King, Washington, United States, at the age of 88, and was buried in Sunset Memorial Park, Hoquiam, Grays Harbor, Washington, United States.