When Seeley Holcombe was born on 12 September 1814, in Pennsylvania, United States, his father, Sterling B Holcomb, was 37 and his mother, Betsey Stone, was 31. He married Julia Ann Wooster on 1 September 1839. They were the parents of at least 1 son and 3 daughters. He lived in Leroy Township, Bradford, Pennsylvania, United States in 1840. He died on 1 August 1849, in United States, at the age of 34, and was buried in Leroy, Leroy Township, Bradford, Pennsylvania, United States.